MovDisordV3, Main, Exploration, bibRecord, 002528

Botulinum Neurotoxins for Post-Stroke Spasticity in Adults : A Systematic Review

Identifieur interne : 002528 ( Main/Exploration ); précédent : 002527; suivant : 002529

Botulinum Neurotoxins for Post-Stroke Spasticity in Adults : A Systematic Review

Auteurs : Antonio Emanuele Elia [Italie] ; Graziella Filippini [Italie] ; Daniela Calandrella [Italie] ; Alberto Albanese [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0223197

Descripteurs français

Pascal (Inist)
- Accident cérébrovasculaire, Hypertonie spastique, Pathologie du système nerveux, Bontoxilysin.

English descriptors

KwdEn :
- Bontoxilysin, Nervous system diseases, Spasticity, Stroke.

Abstract

The aim of this systematic review was to determine whether botulinum neurotoxin (BoNT) reduce spasticity or improve function in adult patients after stroke. Eleven double-blind randomized placebo-controlled trials met inclusion criteria. They encompassed 782 patients, 767 (98%) of whom received BoNT/A, and 15 (2%) BoNT/B. Most studies used the Ashworth scale as primary outcome measure. Differences between treated and control groups were assessed as categorical or continuous comparisons. The overall effect on upper limb spasticity was in favor of BoNT/A. A significantly higher number of patients had a reduction of upper limb spasticity at 4-week and 8-week evaluations in the treatment group compared with placebo. Mean changes in joint spasticity revealed improvement 3 to 6 weeks and 9 to 12 weeks after treatment. There were insufficient data to establish BoNT/A efficacy on lower limb spasticity or the effect of BoNT/B on the upper and lower limbs. Because of inconsistency and heterogeneity of the available data, it was not possible to perform a meta-analysis on disability and patients' reported outcomes. There was an overlapping safety profile between the treatment and the placebo groups. BoNT/ A reduces upper limb spasticity in patients post-stroke, but the improvement in functional ability remains to be established. This gap needs to be filled by new studies to assess the effect of BoNT in the context of multidisciplinary patient management.

Affiliations:

Italie

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of this systematic review was to determine whether botulinum neurotoxin (BoNT) reduce spasticity or improve function in adult patients after stroke. Eleven double-blind randomized placebo-controlled trials met inclusion criteria. They encompassed 782 patients, 767 (98%) of whom received BoNT/A, and 15 (2%) BoNT/B. Most studies used the Ashworth scale as primary outcome measure. Differences between treated and control groups were assessed as categorical or continuous comparisons. The overall effect on upper limb spasticity was in favor of BoNT/A. A significantly higher number of patients had a reduction of upper limb spasticity at 4-week and 8-week evaluations in the treatment group compared with placebo. Mean changes in joint spasticity revealed improvement 3 to 6 weeks and 9 to 12 weeks after treatment. There were insufficient data to establish BoNT/A efficacy on lower limb spasticity or the effect of BoNT/B on the upper and lower limbs. Because of inconsistency and heterogeneity of the available data, it was not possible to perform a meta-analysis on disability and patients' reported outcomes. There was an overlapping safety profile between the treatment and the placebo groups. BoNT/ A reduces upper limb spasticity in patients post-stroke, but the improvement in functional ability remains to be established. This gap needs to be filled by new studies to assess the effect of BoNT in the context of multidisciplinary patient management.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Botulinum Neurotoxins for Post-Stroke Spasticity in Adults : A Systematic Review

Botulinum Neurotoxins for Post-Stroke Spasticity in Adults : A Systematic Review

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri